The course introduces the key considerations when designing and conducting a randomised clinical trial. Throughout the five-day course, delegates will learn why clinical trials are necessary, how different kinds of trials are designed and how bias can be minimised, how trials are managed and then analysed, interpreted and reported. The course will not consider non-randomised trials or other observational designs, or trials evaluating diagnostic tests. We will primarily focus on large multi-centre clinical trials, considering both drug and complex intervention trials.